Crucial for the highly regulated and coordinated paracellular transport are tight junctions, which are continuous networks of interconnected parallel strands at the apical cell poles of adjacent cells.At these sites the membranes of neighboring cells appear to touch resembling kisses according to Diamond ).The two major functions of the tight junction are the gate and the fence function.
They are localized to the apico-lateral region and essential for the epithelial cell transport functions.
The paracellular transport process that occurs via tight junctions is extensively studied and is intricately regulated by various extracellular and intracellular signals.
Fine regulation of this transport pathway is crucial for normal epithelial cell functions.
Among factors that control tight junction permeability are ions and their transporters.
However, this area of research is still in its infancy and much more needs to be learned about how these molecules regulate tight junction structure and functions.
In this review we have attempted to compile literature on ion transporters and channels involved in the regulation of tight junctions.Epithelial cells form highly polarized boundaries between biological compartments to regulate the movements of water, ions, and other solutes between them.Ion and solute transport across an epithelial cell layer can be either via transcellular or paracellular pathways.Congenital cataract is a common major abnormality of the eye, which can result in significant visual impairment or blindness in childhood.In this work, we studied four generations of a Chinese family that exhibited autosomal dominant coralliform cataract but no other ocular or systemic abnormalities.Members of the family were firstly genotyped with microsatellite markers at loci associated with congenital cataract on the reported regions of chromosomes 1, 2, 3, 10, 11, 12, 13, 15, 16, 17, 20, 21, and 22, but negative LOD scores were obtained.